A native Californian, Mitzi Druss has been a performer for most of her life. She started dancing at the age of 4 and by age 8 was acting in commercials. After her 17 year dance career ended Mitzi began studying acting in a conservatory type of environment and acting in numerous plays, among them Our Town and Hopscotch. Eager to get into the realm of comedy Mitzi took classes at Bang studios in Los Angeles and after completing the master class, performed Improv weekly with her ensemble group Blond for over one year. Now she has taken the plunge into standup where she combines what she learned with acting and improv, with her own very unique view of "her world".

Mitzi Druss has appeared at The Comedy Store, The Improv, The Cat Club, Farfalla, Gian Carlos, Goodbar, Dublin's, Martini Lounge, Amagi's, and The Comedy Union.